||Genetic Activity Profiles of Some Chemicals Found in Hazardous Wastes.
Waters, M. D. ;
Stack, H. F. ;
Brady, A. L. ;
||Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Environmental surveys ;
Hazardous wastes ;
Chemical tests ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants. Dose information is collected from the open literature. Genetic activity profiles were prepared for the use of the International Agency for Research on Cancer (IARC) Working Group on Monographs Supplement 6, 'Chemicals, Industrial Processes and Industries Associated with Cancer in Humans'. These profiles will constitute a quantitative data base on the genetic and related effects of approximately 200 chemicals for which some data are available on carcinogenicity in humans. The information will be useful for purposes of comparative chemical assessment and should directly facilitate evaluation of genotoxic chemicals associated with hazardous wastes. Some 34 of the agents reviewed by the IARC are among 100 that have been listed for development of toxicological profiles under the U.S. Superfund Amendments and Reauthorization Act (SARA) of 1986. Genetic toxicity data on an additional seven chemicals listed under SARA are provided in the report.