||Genetic Activity Profiles in the Testing and Evaluation of Chemical Mixtures, June 1990.
Waters, M. D. ;
Claxton, L. D. ;
Stack, H. F. ;
Brady, A. L. ;
Graedel., T. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;A.T. and T. Bell Labs., Murray Hill, NJ.
Salmonella typhimurium ;
Mutagenicity tests ;
Genetic Activity Profile(GAP) ;
Toxic substances ;
Data bases ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Some knowledge of the potential genetic activity of a complex environmental mixture may be gained from an assessment of the genetic activity of its component chemicals. The expanded Genetic Activity Profile (GAP) data base provides a computer-generated graphic representation of genetic bioassay data as a function of dose of the substance tested. In addition, the Atmospheric Chemical Compound (ACC) data base contains information on chemical structures, properties, detection methods and sources of chemicals found in ambient air. Using the combined data bases, information on the quantity of an individual chemical present within a mixture or fraction of a mixture may be related to the quantity (lowest effective dose, LED) of the chemical required to demonstrate a positive response in one or more genetic bioassays. (Copyright (c) 1990 Wiley-Liss, Inc.)