Record Display for the EPA National Library Catalog


Main Title Computer Automated Evaluation of Mutagenicity and Carcinogenicity of Selected Polycyclic Aromatic Hydrocarbons.
Author Mitchell, C. S. ; Klopman, G. ; Rosenkranz, H. S. ;
CORP Author Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-812264; EPA/600/D-89/141;
Stock Number PB90-113416
Additional Subjects Aromatic polycyclic hydrocarbons ; Salmonella typhimurium ; Reprints ; Mutagenicity tests ; Carcinogenicity tests ; Computer automated structure evaluation(CASE) ; Structure-activity relationship
Library Call Number Additional Info Location Last
NTIS  PB90-113416 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The mechanisms by which polycyclic aromatic hydrocarbons (PAHs) induce mutations and cancer have been the subject of considerable attention for several years. Various theoretical and experimental models have been advanced to explain the effects of structural variations on mutagenicity and carcinogenicity. Among these are the BAY region hypothesis developed by Jerina and coworkers, the K and L region hypotheses first proposed by Pullman and Pullman, the radical cation hypothesis, and others. One of the most widely acceptable today is the BAY region hypothesis, based originally on studies of the carcinogenicity of benzo(a)pyrene, that finds the epoxide formed in the BAY region is more carcinogenic than the parent compound itself. This hypothesis has since been extended to other PAHs, and efforts are underway to identify the specific physicochemical characteristics of the region that make it reactive.