Record Display for the EPA National Library Catalog


Main Title Mutagens, Carcinogens, and Computers.
Author Rosenkranz, H. S. ; Klopman, G. ;
CORP Author Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA-R-812664; EPA/600/D-89/140;
Stock Number PB90-116740
Additional Subjects Environmental tests ; Carcinogens ; Mutagens ; Cancer ; Computer applications ; Chemical bonds ; Chemical structure
Library Call Number Additional Info Location Last
NTIS  PB90-116740 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 36p
The increased use of a multitude of short-term tests as predictors of carcinogenicity has brought with it an information explosion which has the potential of either inundating the author with an unmanageable volume of data or it could prove to be invaluable with respect to developing predictive methods as well as providing mechanistic information. The author has been interested in developing methodologies which could use the accumulated data for the latter purposes. Accordingly, the author has taken two approaches which have culminated in the development of CASE (Computer Automated Structure Evaluation method) and CPBS (Carcinogenicity Prediction and Battery Selection method). Each of these, although of proven usefulness, is still undergoing further refinement. In addition, the two approaches can be coupled and the interaction increases predictive capabilities as well as decreasing the cost. (Copyright (c) 1986, Alan R. Liss, Inc.)