Record Display for the EPA National Library Catalog
RECORD NUMBER: 9 OF 21| Main Title | Computer Automated Structure Evaluation of the Carcinogenicity of N-Nitrosothiazolidine and N-Nitrosothiazolidine 4-Carboxylic Acid. | |||||||||||
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| Author | Rosenkranz, H. S. ; Klopman, G. ; | |||||||||||
| CORP Author | Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Publisher | c1987 | |||||||||||
| Year Published | 1987 | |||||||||||
| Report Number | EPA-R-812264; EPA/600/J-88/406; | |||||||||||
| Stock Number | PB90-111584 | |||||||||||
| Additional Subjects | Amines ; Nitroso compounds ; Toxicity ; Reprints ; Computer automated structure evaluation(CASE) ; Carcinogenicity tests ; N-Nitrosothiazolidine ; N-Nitrosothiazolidine-4-carboxylic acid ; Predictive value of tests ; Structure-activity relationship | |||||||||||
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| Collation | 6p | |||||||||||
| Abstract | N-Nitrosothiazolidine 4-carboxylic acid (NTCA), a sulphur-containing nitrosamine present in human urine, was predicted to be non-carcinogenic by CASE, the newly developed Computer Automated Structure Evaluating system. On the other hand, N-nitrosothiazolidine (NTHZ), a nitrosamine present in food products, was predicted to be carcinogenic. The putative non-carcinogenic NTCA may be metabolized to NTHZ, a predicted carcinogen. (Copyright (c) 1987 Pergamon Journals Ltd.) |