Record Display for the EPA National Library Catalog

RECORD NUMBER: 38 OF 61

Main Title Mouse Teratogen Dinocap Has Lower A/D Ratios and Is Not Teratogenic in the Rat and Hamster (Journal Version).
Author Rogers, J. M. ; Barbee, B. ; Burkhead, L. M. ; Rushin, E. A. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/153;
Stock Number PB89-110498
Additional Subjects Environmental surveys ; Genetics ; Fungicides ; Mice ; Laboratory animals ; Hamsters ; Rats ; Toxicity ; Dosage ; Dinocap ; Teratogens ; Mildew
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB89-110498 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract
The fungicide dinocap is currently used in the control of powdery mildew. The authors have reported that dinocap is teratogenic in the CD-1 mouse, causing cleft palate, otolith defects, and fetal weight deficits well below maternotoxic dose levels. In the study the maternal and fetal toxicity of dinocap was determined in the Sprague-Dawley rat and Syrian golden hamster, and Adult-to-Developmental (A/D) toxicity ratios were calculated and compared to the previously established A/D ratio of dinocap in the mouse. The A/D ratios for dinocap in the rat and hamster are similar, and are approximately one. These previous studies have demonstrated that dinocap is teratogenic in the mouse, with an A/D ratio in the range of 8-16 in the species. The basis for the species-specific teratogenicity and inconsistent A/D ratio of dinocap is unknown.