| Main Title |
Effects of Manganese, Calcium, Magnesium, and Zinc on Nickel-Induced Suppression of Murine Natural Killer Cell Activity. |
| Author |
Smialowicz, R. J. ;
Rogers, R. R. ;
Riddle, M. M. ;
Luebke, R. W. ;
Fogelson, L. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/031; |
| Stock Number |
PB87-198404 |
| Additional Subjects |
Toxicity ;
Chemical Compounds ;
Nickel ;
Carcinogens ;
Mice ;
Magnesium ;
Manganese ;
Calcium ;
Zinc ;
NK cells ;
Natural killer cells ;
Antagonists and inhibitors
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-198404 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
The effects that divalent metals have on nickel-induced suppression of natural killer (NK) cell activity were studied in mice. Male CBA/J mice were given a single intramuscular injection of nickel chloride (4.5-36 micrograms NiCl2/g), manganese chloride (20-80 micrograms MnCl2/g), magnesium acetate (50-200 micrograms MgOAc/g), zinc acetate (208 micrograms AnOAc/g) or calcium acetate (12.5-50 micrograms CaOAc/g), and splenic NK cell activity was assessed 24 hours later using a (51)Cr release assay. The data indicate that both the divalent metal and the timing of its injection relative to Ni injection are critical for altering Ni-induced suppression of NK cell activity. (Copyright (c) 1987 by Hemisphere Publishing Corporation.) |
