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Main Title On the Action of Beryllium on Alkaline Phosphatase.
Author Roche, Jean ; Van Thoai, Ngyuyen ; Loewy., Jacqueline ;
CORP Author Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Year Published 1950
Report Number EPA-TR-45-73 ;APTIC-48025;
Stock Number PB-237 729-T
Additional Subjects Alkaline phosphatases ; Beryllium ; Metals ; Inhibition ; Enzymes ; Tissues(Biology) ; Dialysis ; Activation ; France ; Translations ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-237 729-T Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract
The beryllium ion, energetic inhibitor of alkaline phosphatase when the metallic component of the phosphatase has not been disassociated, reactivates the enzyme after prolonged dialysis. It follows from this that, id the Be(++) ion is an energetic inhibitor of alkaline phosphatase in the tissues and their extracts, the modalities of its action on the purified enzyme are identical to those of other cations, particularly Zn(++). The interchangeability of divalent metals in the reactivation of alkaline phosphatase and their competition in the reconstitution of the enzyme molecule disassociated through dialysis appear therefore to be general.