Record Display for the EPA National Library Catalog


Main Title Subacute and Subchronic Toxicity of Ethylene Glycol Administered in Drinking Water to Sprague-Dawley Rats.
Author Robinson, M. ; Pond, C. L. ; Laurie, R. D. ; Bercz, J. P. ; Henningsen., G. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., West Chester, OH. ;Procter and Gamble Co., Cincinnati, OH. ;Harry G. Armstrong Aerospace Medical Research Lab., Wright-Patterson AFB, OH. ;Army Dugway Proving Ground, UT.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/090;
Stock Number PB90-245374
Additional Subjects Toxicity ; Ethylene glycol ; Pathology ; Potable water ; Body weight ; Water consumption ; Food consumption ; Blood chemical analysis ; Kidney ; Reprints ; Sprague-Dawley rats ; Dose-response relationships ; Organ weight ; Sex factors
Library Call Number Additional Info Location Last
NTIS  PB90-245374 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 30p
Subacute (10-day) and subchronic (90-day) toxicity studies of ethylene glycol (EG) were conducted in male and female Sprague-Dawley rats to provide the U.S. Environmental Protection Agency's (EPA) Office of Drinking Water with toxicity data for final preparation of a Health Advisory for the chemical. Ethylene glycol was administered in drinking water at concentrations of 0.5, 1.0, 2.0, and 4.0% for both sexes in the 10-day study. Based on a projected consumption rate of 100 ml/kg/day, the respective doses on a mg/kg/day basis would be 554, 1108, 2216, and 4432. These dose levels were also used in the 90-day study for females, but dose levels for the males in the 90-day study were 0.25, 0.5, 1.0, and 2.0% (227, 554, 1108, and 2216 mg/kg/day). Hemoglobin, hematocrit, erythrocytes, and leukocytes were all significantly decreased in female rats, receiving 4% EG for 10 days. The most significant histopathological findings, seen predominantly in males, were kidney lesions.