Main Title |
Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation. |
Author |
Grose, E. C. ;
Richards, J. H. ;
Jaskot, R. H. ;
Menache, M. G. ;
Graham, J. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;North Carolina State Univ. at Raleigh. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/088; |
Stock Number |
PB88-125539 |
Additional Subjects |
Toxicology ;
Cadmium ;
Enzyme inhibitors ;
Respiration ;
Exposure ;
Lung ;
Liver ;
Laboratory animals ;
Rats ;
Toxicity ;
Reprints ;
Glutathione peroxidase ;
Glutathione transferases ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-125539 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.) |