Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation.
Author Grose, E. C. ; Richards, J. H. ; Jaskot, R. H. ; Menache, M. G. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;North Carolina State Univ. at Raleigh.
Year Published 1987
Report Number EPA/600/J-87/088;
Stock Number PB88-125539
Additional Subjects Toxicology ; Cadmium ; Enzyme inhibitors ; Respiration ; Exposure ; Lung ; Liver ; Laboratory animals ; Rats ; Toxicity ; Reprints ; Glutathione peroxidase ; Glutathione transferases ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-125539 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 11p
A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)