The uptake, distribution and elimination of tin were determined in adult and neonatal (Postnatal Day 5) rat brain following IP administration of triethyltin bromide (TET). Groups of 5 adult CD rats were sacrificed at 10 min, 1 hr, 4 hr, 24 hr, 5 d, or 10 d following acute exposure to 6.0 mg/kg TET; an additional group of adult animals was sacrificed at 24 hr following exposure to either 3.0, 6.0 or 9.0 mg/kg (N=5/dosage). The time course for tin distribution in 5 day-old rat pups was determined by sacrificing pups 10 min, 30 min, 1 hr, 4 hr, 8 hr, 12 hr, 24 hr, 5 d, 10 d, or 22 d following exposure to either 3.0 or 6.0 mg/kg TET (N=4/dosage/time). Tin analyses were performed by flameless atomic absorption spectrophotometry.