| Main Title |
Inhibition of ATPase Activities of Brain and Liver Homogenates by Triethyltin (TET). |
| Author |
Jacobs, K. S. ;
Lemasters, J. J. ;
Reiter, L. W. ;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA-R-809644; EPA/600/D-85/166; |
| Stock Number |
PB85-240646 |
| Additional Subjects |
Adenosine phosphates ;
Brain ;
Liver ;
Inhibitors ;
In vitro analysis ;
In vivo analysis ;
Tin/triethyl ;
ATP
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-240646 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
In vitro, TET is an effective inhibitor of both mitochondrial and Na+/K+-ATPase activities in subcellular fractions from brain and liver. Although TET binds with high affinity to mitochondrial ATPase, it also binds to other cellular constituents including hemoglobin and myelin. Thus, whether or not ATPase inhibition is a factor in the in vivo toxicity of TET may depend on the ability of TET to bind to ATPases in the presence of other cellular constituents. The purpose of this study was to assess inhibition of ATPase activities in liver and brain homogenates in vivo or in vitro exposure to TET. |
