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Main Title Significance of the Dilated Renal Pelvis in the Nitrofen-Exposed Rat Fetus: Effects on Morphology and Function (Journal Version).
Author Kavlock, R. J. ; Hoyle, B. R. ; Rehnberg, B. F. ; Rogers, E. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/154;
Stock Number PB89-110506
Additional Subjects Herbicides ; Pesticides ; Toxicity ; Kidney pelvis ; Pregnancy ; Exposure ; Nitrogen organic compounds ; Morphology ; Kidney functioning tests ; Laboratory animals ; Reprints ; Teratogens ; Nitrofen ; Benzene/dichloro-nitrophenoxy
Library Call Number Additional Info Location Last
NTIS  PB89-110506 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The fate of the dilated renal pelvis that is induced in fetal rats following prenatal exposure to nitrofen was evaluated. Groups of Long Evans rats were exposed to 0, 6.25, 12.5 or 25 mg/kg of nitrofen on gestation days 7-16. Renal morphology of the offspring were determined on gestation day 21 and postnatal week five. The postnatal cohort was tested at two weeks of age for their ability to excrete an osmotically concentrated urine. In addition to confirming the effect on the fetal papilla, a reduced renal concentrating ability in the neonate was demonstrated. As was the case with adriamycin, the poor performance in function test was associated with permanence of the morphological effect. By utilizing a standardized semi-quantitative procedure to describe the status of the kidneys and ureters during development in combination with physiological assessment of organ performance, it was possible to assess the morphological and functional development of the kidney. It is suggested offspring be monitored during postnatal development when alterations of the fetal renal papilla are observed in standard teratology bioassays in order to determine whether the effect is transient or permanent.