||Influence of Time of Exposure to Carbon Tetrachloride on Toxic Liver Injury.
Bruckner, J. V. ;
Luthra, R. ;
Kyle, G. M. ;
Muralidhara, S. ;
Ramanathan, R. ;
||Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. ;Texas Univ., Austin. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Carbon tetrachloride ;
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The study was conducted to determine whether, and by what mechanisms, time of exposure could influence the ability of a model hepatotoxin, carbon tetrachloride (CCl4) to cause liver injury. Rats dosed orally with CCl4 during their active/dark cycle were found to be more susceptible to liver injury than rats dosed during their inactive/light cycle. There was greater hepatic microsomal uptake and metabolism of CCl4 in rats dosed during their active cycle.