Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Immunological Studies in Mice Following In utero Exposure to NiCl2.
Author Smialowicz, R. J. ; Rogers, R. R. ; Riddle, M. M. ; Rowe, D. G. ; Luebke, R. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/072;
Stock Number PB86-214863
Additional Subjects Nickel chloride ; Immunity ; Toxicology ; Bioassay ; Pregnancy ; Mice ; Laboratory animals ; Dosage ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-214863 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 14p
The effect that NiCl2 has on the development of immune function in mice was examined in the offspring of dams implanted with mini-osmotic pumps during pregnancy. Time bred C57BL/6J mice were implanted subcutaneously on day 5 of gestation with mini pumps which delivered a total dose of from 9.1 to 73.2 micrograms/g NiCl2. The pumps delivered NiCl2 to the dams through day 19 of gestation. At 8-10 weeks of age the offspring of NiCl2-dosed dams were evaluated for immune function. No consistent significant alterations were observed between control and treated offspring for the following: lymphoid organ or body weights; the lymphoproliferative response to B or T lymphocyte mitogens; the lymphoproliferative response to allogeneic spleen cells in the mixed lymphocyte reaction; the development of syngeneic tumors; or the primary antibody response to sheep red blood cells. Natural killer (NK) cell activity was reduced in offspring exposed to NiCl2 in utero; however, the biological relevance of these reductions is questionable because of the failure to demonstrate an increased susceptibility to the B16-F10 syngeneic tumor. The results indicate that under the conditions and doses employed it appears that NiCl2 does not adversely affect the developing immune system of the mouse.