Record Display for the EPA National Library Catalog


Main Title Chlorambucil Induced Congenital Renal Hypoplasia: Effects on Basal Renal Function in the Developing Rat.
Author Kavlock, R. J. ; Rehnberg, B. F. ; Rogers, E. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/213;
Stock Number PB87-169611
Additional Subjects Toxicity ; Rat ; Growth abnormalities ; Kidney ; Urologic diseases ; Reprints ; Renal hypoplasia ; Chlorambucil ; Teratology ; Renal function
Library Call Number Additional Info Location Last
NTIS  PB87-169611 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Administration of chlorambucil to pregnant rats on day 11 of gestation induced dose-related alterations in renal growth and function in the postnatal offspring. These effects occurred above and beyond the reductions in body growth and were evident in animals that displayed no overt malformation of the urogenital tract. Reductions in overall growth amounted to 0,6 and 15% in the 3,4.5 and 6 mg/kg groups, respectively, while kidney weights were reduced by 7, 15 and 23%. The weights of the kidneys relative to the body were reduced 5,9 and 10% with increasing dose. Although basal renal function was not affected by the degree of hypoplasia seen in the low dose group, reduced glomerular and tubular function were evident following a basal clearance test in the 2 highest dose groups. The data indicate that chlorambucil induced renal hyopolasia results in reductions in renal function that persist for at least the first 3 weeks after birth in the rat and that physiological assessment of development toxicity can provide an extremely useful addendum to the more classical morphological criteria.