| Main Title |
Influence of Time of Exposure to Carbon Tetrachloride on Toxic Liver Injury. |
| Author |
Bruckner, J. V. ;
Luthra, R. ;
Kyle, G. M. ;
Muralidhara, S. ;
Ramanathan, R. ;
|
| CORP Author |
Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. ;Texas Univ., Austin. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA-R-811215; EPA/600/J-84/272; |
| Stock Number |
PB85-220424 |
| Additional Subjects |
Toxicology ;
Injuries ;
Exposure ;
Liver ;
Rats ;
Laboratory animals ;
Reprints ;
Carbon tetrachloride ;
Hepatotoxins
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-220424 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The study was conducted to determine whether, and by what mechanisms, time of exposure could influence the ability of a model hepatotoxin, carbon tetrachloride (CCl4) to cause liver injury. Rats dosed orally with CCl4 during their active/dark cycle were found to be more susceptible to liver injury than rats dosed during their inactive/light cycle. There was greater hepatic microsomal uptake and metabolism of CCl4 in rats dosed during their active cycle. |
