| Main Title |
Teratologic Evaluation of 2,3,4,6-Tetrachlorophenol (CAS No. 58-90-2) Administered to CD Rats on Gestational Days 6 through 15. Final Report. |
| Author |
George, J. D. ;
Price, C. J. ;
Sleet, R. B. ;
Marr, M. C. ;
Segal, S. A. ;
|
| CORP Author |
Dynamac Corp., Rockville, MD. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Solid Waste. |
| Year Published |
1987 |
| Report Number |
EPA-68-01-7366; EPA/530/SW-88/017A; |
| Stock Number |
PB88-176151 |
| Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Dosage ;
Bioassay ;
Pregnancy ;
Teratogenesis ;
CAS 58-90-2 ;
Tetrachlorophenol
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-176151 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
104p |
| Abstract |
2,3,4,6-Tetrachlorophenol (TCP) was administered by gavage in olive oil to timed-pregnant CD rats at doses of 0, 25, 100, or 200 mg/kg/day on gestational days (gd) 6-15. No significant maternal effects were noted at 25 to 100 mg/kg/day TCP. At 200 mg/kg/day TCP, corrected maternal weight gain was significantly depressed below controls. During the post-treatment period, all TCP-exposed groups consumed significantly more food than the control group. Embryo/fetal growth and prenatal viability were not adversely affected by TCP exposure, nor was there any definitive evidence of an effect of TCP upon fetal morphological development. |
