Record Display for the EPA National Library Catalog


Main Title Methodological Issues in Human Exposure Studies of Low Level Solvent Mixtures.
Author Otto, D. ; Hudnell, H. K. ; Prah, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/341;
Stock Number PB92-233030
Additional Subjects Solvents ; Toxicology ; Irritants ; Neuropsychological tests ; Eye(Anatomy) ; Pharynx ; Inflammation ; Respiratory function tests ; Indoor air pollution ; Reprints ; Volatile organic compounds
Library Call Number Additional Info Location Last
NTIS  PB92-233030 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The design of appropriate studies to assess the sensory irritant and neurobehavioral effects of exposure to complex VOC mixtures poses a variety of methodological challenges, particularly at the low levels found in new buildings. For instance, Otto et al (1989) exposed subjects to a 25 mg/m3 mixture of 22 VOCs representative of the highest concentration encountered in new homes. The concentration is equivalent, in mass, to about 7 ppm toluene. As one might predict, the mixture produced no consistent effects on the performance of an extensive neurobehavioral test battery, but did elicit classical SBS symptoms of eye and throat irritation, headache and fatigue. Failure to find functional deficits could be due to several factors. Perhaps the tests were not sensitive (or difficult) enough to detect effects. The authors used the neurobehavioral evaluation system which was designed for occupational field studies. Further study is needed to determine the optimal testing parameters for use in repeated-measure laboratory studies of university students. Further study is also needed to determine which subsets of the population are most vulnerable to adverse effects of VOC exposure. Finally, other physiological endpoints (e.g., measures of inflammation and pulmonary function) need to be explored.