Record Display for the EPA National Library Catalog


Main Title Behavioral and Neurochemical Changes in Rats Dosed Repeatedly with Diisopropylfluorophosphate.
Author Bushnell, P. J. ; Padilla, S. S. ; Ward, T. ; Pope, C. N. ; Olszyk., V. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northeast Louisiana Univ., Monroe. School of Pharmacy. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/089;
Stock Number PB91-200238
Additional Subjects Animal behavior ; Toxicology ; Organophosphorus compounds ; Neurochemistry ; Cholinesterase inhibitors ; Acetylcholinesterase ; Down-regulation(Physiology) ; Cognition ; Memory ; Motor activity ; Cerebral cortex ; Hippocampus ; Dose-response relationships ; Rats ; Reprints ; Diisopropylfluorophosphate
Library Call Number Additional Info Location Last
NTIS  PB91-200238 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Behavioral effects of organophosphates (OPs) typically decrease with repeated exposure, despite persistence of OP-induced inhibition of acetylcholinesterase (AChE) and downregulation of muscarinic acetylcholine (ACh) receptors. To characterize this tolerance phenomenon, rats were trained to perform an appetitive operant task which allowed daily quantification of working memory (delayed matching-to-position), reference memory (visual discrimination) and motor function (choice response latencies and inter-response times (IRTs) during delay). Findings indicate that animals showing a definitive sign of tolerance to OP administration (subsensitivity to a cholinergic agonist) were also functionally impaired on both the motoric and mnemonic demands of a working memory task. The nature of this impairment suggests further that it results from compensatory changes in the CNS, e.g., muscarinic receptor downregulation, considered to produce 'tolerance' to OPs in exposed animals.