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Main Title Structure-activity relationships and estimation techniques for biodegradation of xenobiotics /
Author Moore, S. A. ; Pope, J. D. ; Barnett, J. T. ; Suarez, L. A.
Other Authors
Author Title of a Work
Moore, Susan A.
CORP Author Environmental Research Lab., Athens, GA.
Publisher U.S. Environmental Protection Agency, Environmental Research Laboratory,
Year Published 1989
Report Number EPA/600/3-89/080
Stock Number PB90-149857
OCLC Number 33320009
Subjects Xenobiotics--Biodegradation ; Biodeterioration ; Chemical reaction kinetics ; Tables(Data) ; Information systems ; Structure-activity relationship Biotransformation ; Cell kinetics
Additional Subjects Biodeterioration ; Chemical reaction kinetics ; Tables(Data) ; Xenobiotics ; Information systems ; Structure-activity relationship Biotransformation ; Cell kinetics
Library Call Number Additional Info Location Last
ELBD RPS EPA 600-3-89-080 repository copy AWBERC Library/Cincinnati,OH 06/26/2018
EMBD  EPA/600/3-89/080 NRMRL/GWERD Library/Ada,OK 10/27/1995
NTIS  PB90-149857 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 108 pages : illustrations ; 28 cm
The current status of structure-activity relationships for the biodegradation of xenobiotics is reviewed. Results are presented of a pilot study on biodegradation constants obtained from computer databases. New analyses for a relatively large number of anilines and phenols are presented in which the kinetic constants for biodegradation successfully correlate with the pKa's of the ionizing groups. The use of molecular connectivity indices is reviewed. These indices have broad application over a wide array of chemical classes in structure-biodegradability relationships, and they have the benefit of being purely calculated parameters. It is proposed that the biodegradability of complex molecules and polymers containing labile R-X-R' linkages may be accurately estimated based on the biodegradability of their component parts, where X is one or more heteroatom. Estimation techniques are reviewed with respect to the kinetic processes that are associated with biodegredation.
"November 1989." "EPA/600/3-89/080." Includes bibliographical references (page 6).