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Main Title Long-Term Neurochemical and Behavioral Effects Induced by Acute Chlorpyrifos Treatment.
Author Pope, C. N. ; Chakraborti, T. K. ; Chapman, M. L. ; Farrar, J. D. ;
CORP Author Northeast Louisiana Univ., Monroe. School of Pharmacy.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/256;
Stock Number PB92-206366
Additional Subjects Dursban ; Toxicology ; Neurochemistry ; Motor activity ; Cholinesterase inhibitors ; Corpus striatum ; Cerebral cortex ; Muscarinic receptors ; Rats ; Binding sites ; Scopolamine ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-206366 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
A single, maximal tolerated dose of the organophosphate insecticide chlorpyrifos (CPF, 279 mg/kg, sc) caused extensive inhibition of striatal and cortical cholinesterase (ChE) activity in adult rats at two (94-96%), four (64-74%) and six (36-38%) weeks after treatment. These persistent changes in ChE activity were concomitant with significant reductions in striatal muscarinic receptor (3H quinuclidinyl benzilate) binding sites (50, 31 and 18% reduction in B max at 2, 4 and 6 weeks after exposure) and a slight but significant alteration in the apparent affinity constant, K(D), at 2 and 4 weeks after treatment. Neither ChE activity nor muscarinic receptor binding were different from control levels at 12 weeks after exposure. CPF treatment caused a significant reduction in motor activity for the first two days after treatment, after which basal activity levels were not different from controls. These data indicate that a single, acute exposure to CPF in adult rats can cause long-term neurobehavioral/neuropharmacological changes which may persist following the recovery of neurochemical parameters generally associated with OP exposure and/or tolerance.