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Main Title Relationships of Quantitative Structure-Activity to Comparative Toxicity of Selected Phenols in the 'Pimephales promelas' and 'Tetrahymena pyriformis' Test Systems.
Author Schultz, T. W. ; Holcombe, G. W. ; Phipps, G. L. ;
CORP Author Tennessee Univ., Knoxville.;Environmental Research Lab.-Duluth, MN.
Year Published 1986
Report Number EPA-R-810791; EPA/600/J-86/319;
Stock Number PB87-176616
Additional Subjects Toxicity ; Phenols ; Toxic tolerances ; Linear regression ; Narcosis ; Phosphorylation ; Reprints ; Pimephales promelas ; Fathead minnow ; Tetrahymena pyriformis ; Ciliate protozoan
Library Call Number Additional Info Location Last
NTIS  PB87-176616 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The relative toxic response of 27 selected phenols in the 96-hr acute flowthrough Pimephales promelas (fathead minnow) and the 48- to 60-hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems was evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of two linear equations. The less toxic chemicals form a relationship which models polar narcosis: these chemicals are slightly more active than the baseline toxicity of nonionic narcotic chemicals. The more toxic chemicals form a relationship which models uncouplig of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log LC50 (mol/liter)) vs Tetrahymena toxicity (log BR (mmol/liter)) showed good correlation between the two systems. An exception appears to be 4-nitrophenol, which is more active in the Tetrahymena system than in the fathead minnow and lies outside the 95% confidence interval. Reanalysis following deletion of 4-nitrophenol results in the equation log LC50 = -0.9192 (log BR) - 3.5035; n = 26, r(2) = 0.887. (Copyright (c) 1986 Academic Press, Inc.)