||Quantitative Assessment of Cancer Risk from Exposure to Diesel Engine Emissions.
Pepelko, W. E. ;
Chen, C. ;
||Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Pulmonary neoplasms ;
Diesel engine exhaust ;
Coal tar ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Quantitative estimates of lung cancer risk from exposure to diesel engine emissions were developed using data from three chronic bioassays with Fischer 344 rats. Human target organ dose was estimated with the aid of a comprehensive dosimetry model. The epithelial tissue lining the alveoli and lower airways is the primary target site for induction of lung tumors. Dose was therefore based upon the concentration of carbon particulate matter per unit lung surface area.