| Main Title |
Effect of Chloroquin on Hepatic Microsomal Enzyme of the Squirrel Monkey. |
| Author |
Cranmer, M. ;
Peoples., A. ;
|
| CORP Author |
Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab. |
| Year Published |
1971 |
| Stock Number |
PB-277 604 |
| Additional Subjects |
Drugs ;
Antimalarials ;
Liver ;
Physiological effects ;
Ingestion(Biology) ;
Ribosomes ;
Enzymes ;
Monkeys ;
Quinolines ;
Bioassay ;
Laboratory animals ;
Reprints ;
Quinoline/chloro-(((diethylamino)-methylbutyl)amino) ;
Chloroquine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-277 604 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1p |
| Abstract |
The present work was done to examine the possible effect on the hepatic microsomal enzymes and P-450 content of squirrel monkeys treated with chloroquin. Chloroquin was found to stimulate the o-demethylation of p-nitroanisole and the oxidative hydrolysis of EPN but not to increase hepatic P-450. A 30-day 10 mg kg/day chloroquin pretreatment to 4 adult male squirrel monkeys blocked the stimulation of P-450 by a 3 day 5 mg/kg administration of p,p'-DDT and decreased the stimulation of hepatic microsomal enzymes by p,p'-DDT. |
