Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 10

OLS Field Name OLS Field Data
Main Title Oral Ingestion of 'Legionella pneumophila'.
Author Plouffe, J. F. ; Para, M. F. ; Fuller, K. A. ; Bollin, G. E. ;
CORP Author Ohio State Univ., Columbus. Div. of Infectious Diseases.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-812704 ;EPA-4-811023; EPA/600/J-86/253;
Stock Number PB87-169132
Additional Subjects Ingestion(Biology) ; Gastrointestinal tract ; Pathology ; Potable water ; Contaminants ; Immunology ; Guinea pigs ; Reprints ; Legionella pneumophila ; Legionnaires disease ; Cimetidine
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB87-169132 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract
Guinea pigs were fed L. pneumophila through an orogastric tube. Gastric acid was rapidly cidal to the organisms. Serial necropsies demonstrated the organisms in the colon and blood stream at 1 hour. Guinea pigs fed large doses of L. pneumophila seroconverted. Previously fed guinea pigs were then challenged with a lethal intraperitoneal dose of L. pneumophila and were protected in a dose-dependent fashion. Pretreatment of the guinea pigs with cimetidine lowered the dose of oral L. pneumophila required for protection. The model may be useful in studying the immune response after oral ingestion of L. pneumophila. (Copyright (c) 1986, Teviot-kimpton Publications.)