||Oral Ingestion of 'Legionella pneumophila'.
Plouffe, J. F. ;
Para, M. F. ;
Fuller, K. A. ;
Bollin, G. E. ;
||Ohio State Univ., Columbus. Div. of Infectious Diseases.;Health Effects Research Lab., Research Triangle Park, NC.
||EPA-R-812704 ;EPA-4-811023; EPA/600/J-86/253;
Gastrointestinal tract ;
Potable water ;
Guinea pigs ;
Legionella pneumophila ;
Legionnaires disease ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Guinea pigs were fed L. pneumophila through an orogastric tube. Gastric acid was rapidly cidal to the organisms. Serial necropsies demonstrated the organisms in the colon and blood stream at 1 hour. Guinea pigs fed large doses of L. pneumophila seroconverted. Previously fed guinea pigs were then challenged with a lethal intraperitoneal dose of L. pneumophila and were protected in a dose-dependent fashion. Pretreatment of the guinea pigs with cimetidine lowered the dose of oral L. pneumophila required for protection. The model may be useful in studying the immune response after oral ingestion of L. pneumophila. (Copyright (c) 1986, Teviot-kimpton Publications.)