Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Sulfamethoxazole-Trimethoprim Treatment of Guinea Pigs Infected with 'Legionella pneumpophila'.
Author Plouffe, J. F. ; Para, M. F. ; Bollin, G. E. ;
CORP Author Ohio State Univ., Columbus. Div. of Infectious Diseases.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-812704; EPA/600/J-84/393;
Stock Number PB87-169181
Additional Subjects Bacterial pneumonia ; Drug therapy ; Antibiotics ; Guinea pigs ; Laboratory animals ; In vivo analysis ; Reprints ; Legionnaires disease ; Legionella pneumophila ; Sulfamethoxazole-trimethoprim
Library Call Number Additional Info Location Last
NTIS  PB87-169181 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 5p
Legionnaires' disease is a bacterial pneumonia caused by Legionella pneumophila. Many antibiotics inhibit the growth of L. pneumophila in vitro, but only erythromycin and rifampin have been clinically effective. Parallel results have been observed in guinea pigs infected ip with L. pneumophila. Antibiotics that were ineffective in this model include penicillin, tetracycline, chloramphenicol, gentamicin, and many cephalosporins. Using the guinea pig model, the authors studied the in vivo efficacy of sulfamethoxazole-trimethoprim. (Copyright (c) 1984 by the University of Chicago.)