Record Display for the EPA National Library Catalog


Main Title Synaptonemal Complex Damage as a Measure of Chemical Mutagen Effects on Mammalian Germ Cells.
Author Allen, J. W. ; DeWeese, G. K. ; Gibson, J. B. ; Poorman, P. A. ; Moses, M. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Duke Univ. Medical Center, Durham, NC.
Year Published 1987
Report Number EPA/600/J-87/028;
Stock Number PB87-198461
Additional Subjects Genetics ; Mutations ; Germ cells ; Chromosomes ; Toxicology ; Mitomycins ; Cyclophosphamide ; Reproductive system ; Reprints ; Synaptonemal complex ; Enviromental pollutants ; Health hazards ; Meiosis ; Mutagenicity tests ; Genetic toxicity tests
Library Call Number Additional Info Location Last
NTIS  PB87-198461 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
As heritable chromosome anomalies are implicated in a variety of human disabilities, their induction in germ cells by environmental chemicals is viewed as a threat to health. Synaptonemal complex (SC) analysis is a novel approach for the detection of germ-line chromosomal damage. This sensitive cytological procedure reveals induced structural damage and pairing abnormalities in SCs of meiotic prophase chromosomes, together with other germ-line toxic effects, in the testes of rodents treated with mitomycin C and cyclophosphamide. Our results demonstrate the effectiveness of SC analysis as a rapid and practical in vivo germ-line mutagen assay that lacks many of the shortcomings of existing tests. (Copyright (c) 1987 Elsevier Science publishers B.V. Biomedical Division.)