| Main Title |
Structure-Activity Relationship Studies on the Toxicities of Benzene Derivatives: 1. An Additivity Model. |
| Author |
Hall, L. H. ;
Kier, L. B. ;
Phipps, G. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. ;Medical Coll. of Virginia, Richmond. ;Eastern Nazarene Coll., Quincy, MA. Dept. of Chemistry. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/202; |
| Stock Number |
PB85-157006 |
| Additional Subjects |
Toxicity ;
Benzenes ;
Mathematical models ;
Water pollution ;
Physical properties ;
Fishes ;
Exposure ;
Dosage ;
Concentration(Composition) ;
Water analysis ;
Chemical analysis ;
Reprints ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-157006 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
A quantitative structure-activity analysis was performed on a series of substituted benzenes for which toxicity values have been obtained over 96 h in the fathead minnow. The authors have determined the additive contribution to several substituent groups. They have found a decreasing contribution to toxicity to be Cl > Br > NO2 > CH3 > OCH3 > NH2 > OH. This additivity model, expressed as an equation, yields a correlation coefficient (r) of 0.951, compared with the log of the lethal concentration (LC50). The positional dependence of substituents on benzene has been studied, as has the relationship between the substituent toxicity ranking and physical properties. (Copyright (c) 1984 SETAC.) |
