Record Display for the EPA National Library Catalog


Main Title Acute Effects and Long-Term Sequelae of 1,3-Dinitrobenzene on Male Reproduction in the Rat. 2. Quantitative and Qualitative Histopathology of the Testis.
Author Hess, R. A. ; Linder, R. E. ; Strader, L. F. ; Perreault, S. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/375;
Stock Number PB90-103086
Additional Subjects Toxicology ; Reproduction(Biology) ; Pathology ; Testis ; Males ; Rats ; Reprints ; Dinitrobenzenes ; Biological effects ; Spermatozoa ; Seminiferous tubules
Library Call Number Additional Info Location Last
NTIS  PB90-103086 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
The study determined the quantitative and qualitative histopathologic effects of a single oral dose of 1,3-dinitrobenzene (48 mg/kg) on the rat testis from 1 to 175 days postexposure. The testis was damaged severely by hour 24, as evidenced by increased numbers of regressive seminiferous tubules that exhibited degenerating pachytene spermatocytes, chromatin margination in spermatids, and reduced numbers of meiotic figures. The major effects during the first 48 hours posttreatment were degeneration or exfoliation of pachytene spermatocytes and round spermatids and the retention of step 19 spermatids. These regressive effects continued until 24 days, after which the tubules either recovered or became atrophic. At the end of the study (175 days), three males were normal, one had regressed testicles, and three males had atrophic tubules (15 to 45%). Several cellular abnormalities were common throughout the period.