||Influence of the Formamidine Pesticide Chlordimeform on Ovulation in the Female Hamster; Dissociable Shifts in the Luteinizing Hormone Surge and Oocyte Release.
Goldman, J. M. ;
Stoker, T. E. ;
Perreault, S. D. ;
Cooper, R. L. ;
Crider, M. A. ;
||ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch.
Dose-response relationships ;
Biological models ;
Time factors ;
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The present experiments were designed to investigate the effects of chlordimeform (CDF) on ovulation in the golden hamster and whether any observed alterations are associated with differences in the appearance of the surge. Additional experiments demonstrated that this effect was due to a delay in ovulation and not a decrease in the complement of oocytes released. Characterization of the LH surge indicated that there was a dose-related delay, but that this effect was not sufficient to account for the delay in ovulation. The results indicate that CDF given at a time just prior to the preovulatory rise in LH is able to impede ovulation in the hamster by possibly influencing some ovulatory event(s) triggered by the surge.