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Main Title Analysis of the Genotoxicity of Anthraquinone Dyes in the Mouse Lymphoma Assay.
Author Harrington-Brock, K. ; Parker, L. ; Doerr, C. ; Cimino, M. C. ; Moore, M. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/016;
Stock Number PB91-183509
Additional Subjects Anthraquinones ; Dyes ; Mutagenicity tests ; Thymidine kinase ; Metabolic activation ; Carcinogenicity tests ; Mutation ; Tables(Data) ; Cell survival ; Reprints ; Mouse lymphoma assay
Library Call Number Additional Info Location Last
NTIS  PB91-183509 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Despite their widespread use and potential for significant human exposure, genotoxicity data on anthraquinones and other dyes are generally limited. The study examined 16 anthraquinones and one azo dye (Solvent Red 1) using the thymidine kinase (tk) locus and micronucleus (MN) analysis in L5178Y/TK(sup +/-) -3.7.2C mouse lymphoma cells. Disperse Blue 7, 2-aminoanthraquinone, 1-amino-2-methylanthraquinone, Disperse Blue 3, and Disperse Red 11 were genotoxic. Reactive Blue 19 was weakly mutagenic. Vat Yellow 4 and Solvent Red 1, with exogenous activation, were also mutagenic. With activation 1-nitro-2-methylanthraquinone was judged to give an equivocal mutagenicity response. Those chemicals that did not induce mutation or cytotoxicity at the limits of solubility were classified separately. Compounds which were not evaluated without exogenous activation because of insolubility but were evaluated with activation include 1-nitro-2-methylanthraquinone, Solvent Red 1, and Vat Yellow 4. Compounds which were not evaluated either with or without S-9 activation because of their insolubility in the culture medium include 1-amino-2,4-dibromoanthraquinone, D&C Green, Disperse Blue 1, Disperse Red 60, Vat Blue 4, Vat Blue 20, Vat Brown 1, and Vat Brown 3.