Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 3
|Main Title||Chemical of current interest propylene oxide : health and environmental effects profile /|
|Author||Meylan, W. ; Papa, L. ; De Rosa, C. T. ; Stara, J. F.|
|CORP Author||Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.|
|Publisher||U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria and Assessment Office,|
|Additional Subjects||Propylene oxide ; Toxicology ; Water pollution ; Chemical properties ; Environmental transport ; Industries ; Exposure ; Carcinogens ; Rodents ; Dosage ; Risk ; Assessments ; Reprints ; Occupational health and safety|
|Collation||44 pages ; 28 cm|
The article reviews all of the relevant information on propylene oxide including physical and chemical properties, environmental fate and transport processes, exposure (water, food, inhalation and dermal), pharmacokinetics, effects (carcinogenicity, mutagenicity, teratogenicity, other reproductive effects and chronic toxicity), aquatic toxicity, existing guidelines and standards, and develops risk assessments. The available toxicological data regarding propylene oxide indicate that the compound is a contact carcinogen in rodents, causing stomach tumors following ingestion and nasal tumors after inhalation exposure. Applying the cancer guidelines, propylene oxide is most appropriately classified as a group B2 chemical.
"Journal article." "EPA/600/J-86/502." "Published in Toxicology and Industrial Health, 2(3):219-260 (1986)." Microfiche.