One of the problems encountered in studies of glue sniffing, and other types of solvent poisoning is addiction. This problem also afflicts researchers who tend to become addicted to a particular methodology. This paper will review some alternatives to the behavioral methods to which many of us have become addicted. These alternatives include sensory evoked potentials and event-related slow potentials of the brain. Evoked potentials are sensitive, clinically proven, indices of sensory deficits, while event-related slow potentials are sensitive, albeit experimental, indices of cognitive dysfunction. Evidence is accumulating that evoked and slow potential measures may also be sensitive indices of neurotoxic effect.