Record Display for the EPA National Library Catalog


Main Title Reproductive and Thyroid Effects of Low-Level Polychlorinated Biphenyl (Aroclor 1254) Exposure.
Author Gray, L. E. ; Ostby, J. ; Marshall, R. ; Andrews, J. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-93/397;
Stock Number PB93-236347
Additional Subjects Reproduction(Biology) ; Aroclors ; Thyroid gland ; Thyroid hormones ; Rats ; Testis ; Sperm motility ; Organ weight ; Testosterone ; Body weight ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236347 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The current study was conducted to evaluate the effects of subchronic administration of Aroclor 1254 on testicular gamete production and endocrine function. The thyroid hormone thyroxine (T4), which is critical for reproduction and development, was also measured because of the well-documented effects of PCBs on this hormone. Weanling (31-day-old) male Fischer rats were administered 0, 0.1, 1, 10, or 25 mg/kg/day Aroclor 1254 by gavage for 5, 10, or 15 weeks and necropsied. In the high-dose group, body, seminal vesicle, cauda epididymal, and pituitary weights were depressed at 10 and 15 weeks and cauda epididymal sperm numbers were reduced after 15 weeks of dosing. In contrast, testes weights, testicular sperm numbers, sperm motility, and serum and testicular testosterone levels were unaffected, even in the highest dose group (25 mg/kg/day). Aroclor 1254 administration produced histological alterations in the liver and kidney at doses of 1.0 mg/kg/day and above. These results indicate that the testis of the rat is not a specific target organ for Aroclor 1254.