Record Display for the EPA National Library Catalog


Main Title Do Sympathetic Neurons Coordinate Cellular Development in the Heart and Kidney. Effects of Neonatal Central and Peripheral Catecholaminergic Lesions on Cardiac and Renal Nucleic Acids and Proteins.
Author Slotkin, T. A. ; Levant, B. ; Orband-Miller, L. ; Queen, K. L. ; Stasheff., S. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA-R-813769; EPA/600/J-88/517;
Stock Number PB90-233974
Additional Subjects Nerve cells ; Sympathetic nervous system ; Catecholamines ; Proteins ; Nucleic acids ; Heart ; Kidney ; Graphs(Charts) ; Body weight ; Central nervous system ; Peripheral nervous system ; Reprints ; Weaning ; Organ weight ; Newborn animals
Library Call Number Additional Info Location Last
NTIS  PB90-233974 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Sympathetic nerve activity has been hypothesized to set the timing of cellular maturational events in target tissues. In the study, this hypothesis was tested by lesioning catecholamine pathways in the periphery and central nervous system through the use of subcutaneous or intracisternal injections of 6-hydroxydopamine. Systemically administered 6-hydroxydopamine completely depleted peripheral norepinephrine. The central treatment completely ablated the development rise in brain norepinephrine and dopamine and had little effect on peripheral norepinephrine levels, but has been shown to reduce sympathetic tone. In both the heart and the kidney, either type of lesion resulted in deficits in cell acquisition (DNA) with some evidence of compensatory increases in other macromolecules involved in cell enlargement (particularly RNA), thus maintaining the tissue growth rate at only slightly abnormal levels. The peak effect was always seen during the stages at which sympathetic neuronal synaptogenesis and impulse activity ordinarily undergo their most rapid development. Most of the 6-hydroxydopamine-induced differences in nucleic acids lessened or disappeared toward weaning, and thus the data support the view that sympathetic neuronal input influences the timing of maturational control of macromolecules, but not their final set-point. (Copyright (c) 1988 The American Society for Pharmacology and Experimental Therapeutics).