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Main Title Toxicokinetics and Structure-Activity Relationships of Nine Para-Substituted Phenols in Rat Embryos In vitro.
Author Fisher, H. L. ; Sumler, M. R. ; Shrivastava, S. P. ; Edwards, B. ; Oglesby, L. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/063;
Stock Number PB94-143740
Additional Subjects Pharmacokinetics ; Toxicology ; Phenols ; Rats ; In vitro analysis ; Embryos ; Dosage ; Isotopic labeling ; Metabolites ; Membranes(Biology) ; Regression analysis ; Reprints ; Para-substituted phenols ; Developmental toxicokinetics
Library Call Number Additional Info Location Last
NTIS  PB94-143740 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The purpose of the study was to examine the toxicokinetics of embryo uptake following exposure to a variety of chemically related phenols in rat embryo culture. The uptake of nine radiolabeled para-substituted phenols by day 10 (9-13 somite stage) rat embryos in vitro was determined from 1 to 42 hrs after being placed in culture media containing various phenols. When hepatocytes were also present in the media the equilibrium concentration in the embryos was less than when hepatocytes were absent. Thus the metabolites produced by the hepatocytes appeared to have less affinity for the embryo than the parent phenol. Toxicodynamic information as given by the effective concentration of the phenol in the embryo to cause somite or tail teratological effects was best predicted by the measured unbound fraction. (Copyright (c) 1993 Wiley-Liss, Inc.)