Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Single-Breath Diffusing Capacity and Lung Volumes in Small Laboratory Mammals.
Author Takezawa, Jun ; Miller, Fred J. ; O'Neil, John J. ;
CORP Author National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-80-249;
Stock Number PB81-184780
Additional Subjects Carbon monoxide ; Lung ; Laboratory animals ; Capacity ; Diffusion ; Mammals ; Residues ; Comparative physiology ; Hamsters ; Rats ; Guinea pigs ; Rabbits ; Body weight ; Hyperventilation ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB81-184780 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
The authors measured the single-breath diffusing capacity for carbon monoxide (DLco), total lung capacity(TLC), functional residue capacity(FRC), and residual volume(RV) in anesthetized male hamsters, rats, guinea pigs, and rabbits whose weights varied from 40 to 3,500g. TLC (defined as an airway pressure of 25 cmH20) was calculated by neon dilution. The DLco was estimated by a modification of the single-breath method. There was a high correlation between body weight and the measurement of both the diffusing capacity and the lung volumes. No significant difference in DLco was observed in rats when measured in different body positions, at airway pressures of 10 or 20 cmH20, from FRC or RV, in male or female rats, or following hyperventilation.