Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Tissue Slices in the Study of Lung Metabolism and Toxicology.
Author Freeman, B. A. ; O'Neil, J. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Year Published 1984
Report Number EPA/600/J-84/111;
Stock Number PB85-106268
Additional Subjects Toxicology ; Models ; Lung ; Metabolism ; Tissues(Biology) ; Dosage ; Responses ; Respiratory system ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB85-106268 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 12p
Lung tissue slices are model systems for the study of pulmonary metabolism. Because of the speed and simplicity of slice preparation, lung slices have been used in studies of oxygen, amino acid, carbohydrate and lipid utilization and adenine nucleotide metabolism. Dose-response characteristics for toxicants are readily described because multiple lung samples can be studied from the same animal or a population of animals. Lung slices prepared from animals exposed to oxidant air pollutants exhibit alterations in respiration, glucose consumption and lipid metabolism. These studies have indicated both direct toxic effects of air pollutants on enzyme systems and also air pollutant-induced changes in the cellularity of lungs.