||Ozone-Induced Changes in the Pulmonary Clearance of (99m)Tc-DTPA in Man.
Kehrl, H. R. ;
Vincent, L. M. ;
Kowalsky, R. J. ;
Horstman, D. H. ;
O'Neil, J. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ., Chapel Hill.
Health effects ;
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Ozone is a respiratory irritant that has been shown in animals to increase the premeability of the respiratory epithelium. In the study the authors have recently reported that respiratory epithelial permeability was similarly affected in eight healthy non-smoking young men exposed to ozone (ARRD, 135 (1987) 1124-8). Permeability was evaluated by determining the pulmonary clearance of inhaled aerosolized 99mTc-DTPA with sequential posterior lung imaging by a computer-assisted gamma camera. In a randomized crossover design, 16 young men were exposed for 2 h to purified air and 0.4 ppm ozone while performing intermittent high intensity treadmill exercise; forced vital capacity (FVC) was measured before and at the end of exposures. The results demonstrate that ozone exposure increased respiratory epithelial permeability. Such an increase may be a manifestation of direct ozone-induced epithelial cell injury, lung inflammation or both.