Record Display for the EPA National Library Catalog


Main Title Dynamics of Polychlorinated Biphenyls in Striped Bass from the Hudson River. 3. Tissue Disposition and Routes for Elimination.
Author O'Connor, J. M. ; Pizza, J. C. ;
CORP Author New York Univ. Medical Center, Tuxedo Park. Inst. of Environmental Medicine.;Environmental Research Lab., Gulf Breeze, FL.
Year Published 1987
Report Number EPA-R-808006; EPA/600/J-87/191;
Stock Number PB88-161344
Additional Subjects Bass ; Exposure ; Elimination ; Concentration(Composition) ; Tissues(Biology) ; Hudson River ; Toxicology ; Reprints ; Polychlorinated biphenyls ; Bioccumulation ; Ecological concentrations
Library Call Number Additional Info Location Last
NTIS  PB88-161344 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Striped bass were exposed to 14C-polychlorinated biphenyls (PCB) in single-dose and multiple-dose experiments. Samples were analyzed to determine rate constants for PCB elimination from individual tissues, PCB concentration in tissues, the proportion of the PCB burden retained and the proportion of the cumulative dose retained by each tissue at various times after exposure. An experiment was also conducted to determine both the potential for secondary PCB uptake in dietary exposure studies and the relative tissue disposition of PCBs assimilated from dietary sources as compared to direct water uptake. PCBs were present in the tissues of striped bass within 6 h after administration of a single dose. Certain tissue compartments, such as the liver/gall bladder, accumulated PCBs over a period of 48 h even though the whole-body burden had decreased between 24 and 48 h. The most likely route for PCB elimination from striped bass was from tissues to the liver and thence to the intestine via the bile. There were no differences in the tissue disposition of PCB related to route of exposure. (Copyright (c) 1987 Estyarine Research Foundation.)