Record Display for the EPA National Library Catalog

RECORD NUMBER: 28 OF 37

Main Title Neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC).
Author Miller, D. B. ; Luebke, R. W. ; Reinhard, J. ; O'Callaghan., J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/191;
Stock Number PB91-231092
Additional Subjects Toxicity ; Nervous system ; Diethyldithiocarbamate ; Immune system ; Dose-response relationships ; Drug synergism ; Spleen ; Thymus gland ; Tyrosine hydroxylase ; Organ weight ; Concanavalin A ; Phytohemagglutinins ; Methylphenyltetrahydropyridine
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB91-231092 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract
The T-cell suppression induced by the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be reversed if treatment is preceeded by low dosages of diethyldithocarbamate (DDC). However, if the dosage of DDC is high enough to potentiate the neurotoxicity associated with MPTP, thymic and spleen involution occur suggesting this dosing regimen may impair immune function. Thus, the immunotoxic and neurotoxic effects of the high dose regimen were studied.