||Formation of Benzo(a)pyrene/DNA Adducts and Their Relationship to Tumor Initiation in Mouse Epidermis.
Ashurst, S. W. ;
Cohen, G. M. ;
Nesnow, S. ;
DiGiovanni, J. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Aromatic polycyclic hydrocarbons ;
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The tumorigenicity of benzo(a)pyrene(B(a)P) applied topically as a skin tumor initiator in Sencar mice and the formation of epidermal B(a)P/deoxyribonucleoside adducts were compared over a similar range of doses (50) to 1600 nmol. The tumor initiating activity of B(a)P, its covalent binding to mouse epidermal DNA, and the formation of the major hydrocarbon/deoxyribonucleoside adduct showed approximately parallel dose-response curves.