Record Display for the EPA National Library Catalog

RECORD NUMBER: 42 OF 83

Main Title Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
Author Fischer, S. M. ; Ogle, S. ; Marnett, L. J. ; Nesnow, S. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Oak Ridge National Lab., TN. ;Wayne State Univ., Detroit, MI. Dept. of Chemistry.
Year Published 1983
Report Number EPA-600/J-83-166;
Stock Number PB84-170968
Additional Subjects Toxicology ; Mutagens ; Mice ; Skin(Anatomy) ; Reprints ; Carcinogenesis ; Malondialdehyde
Holdings
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Status
NTIS  PB84-170968 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract
Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.