Record Display for the EPA National Library CatalogRECORD NUMBER: 9 OF 22
|Main Title||Inhibition of Microsomal Metabolism and Chemical Oncogenesis in Culture by Naphthalene Quinones.|
|Author||Nesnow, Stephen ; Bergman, Hinda ; Garland, Helen ; Morris, Mary ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Ribosomes ; Inhibition ; Metabolism ; Liver ; Rats ; Reprints ; Oncogenesis ; Naphthalene quinones|
A series of napthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase activities in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-MC) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9,10-quinone was the most active compound tested with a K1=0.79 uM.