| Main Title |
Inhibitation of Benzo(A)Pyrene Monooxygenase by alpha-Naphthoflavone may be Partially Mediated by the Metabolite 9-Hydroxy-alpha-Naphthoflavone. |
| Author |
Nesnow, Stephen ;
Easterling, Robert ;
Bergman, Hinda ;
Roth, Robert ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-600/J-82-153; |
| Stock Number |
PB83-189654 |
| Additional Subjects |
Inhibitors ;
Rats ;
Liver ;
Microsomes ;
Metabolism ;
Reprints ;
Metabolites ;
Benzopyrene monooxygenase ;
Naphthoflavone ;
Naphthoflavone/hydroxy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-189654 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Naphthoflavone (ANF) inhibits beta-naphthoflavon-induced rat liver microsomal benzo(a)pyrene metabolism and is transformed by these microsomes into naphthoflavone metabolites. The authors determined the inhibitory effect on benzo(a)pyrene (B(a)P) metabolism of several of these metabolites and of 6-methoxy-ANF, using beta-naphthoflavone-induced rat liver microsomes. 9-Hydroxy-ANF was the most active inhibitor (I50 = 1.47 micro M) and was metabolized from ANF by these hepatic cimrosomes in concentrations which are inhibitory. Therefore, 9-hydroxy-ANF a microsomal metabolite of ANF, may play a role in the inhibition of B(a)P oxidation by ANF. |
