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RECORD NUMBER: 6 OF 22

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Main Title

Identification of Cocarcinogens and Their Potential Mechanisms of Action Using C3H10T(1/2)CL8 Mouse Embryo Fibroblasts.

Author

Nesnow, Stephen ; Leavitt, Sharon ; Garland, Helen ; Vaughan, T. Owens ; Hyatt, Betty ;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1981

Report Number

EPA-600/J-80-202;

Stock Number

PB82-247206

Additional Subjects

Carcinogens ; Toxicology ; Identifying ; Mice ; Reprints ; Fibroblasts ; Fetuses

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB82-247206	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

The cocarcinogenic action of five agents which increase microsomal mixed-function oxidase activity in vivo was examined in the C3H101/2CL8 transformation assay. The compounds studies were benz(a)anthracene, 5,6-benzoflavone, phenobarbital, pregnenolone-16a-carbon-nitrile, and Aroclor 1254. After a 48-hr pretreatment with the agent, the cells were then treated with benzo(a)pyrene (B(a)P) and the agent for an additional 24hr. This suggests that these agents exert their cocarcinogenic action via increases in the enzyme-mediated pathways of B(a)P metabolism.

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