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Main Title Relationship between Tumorigenic Potency, Ki-ras Codon 12 Mutations, and DNA Adducts Induced by Cyclopenta(cd)pyrene.
Author Nesnow, S. ; Ross, J. A. ; Nelson, G. ; Wilson, K. ; Roop, B. C. ;
CORP Author Medical Coll. of Ohio at Toledo. Dept. of Pathology. ;Ohio State Univ., Columbus. Dept. of Preventive Medicine. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Integrated Lab. Systems, Research Triangle Park, NC.;Environmental Protection Agency, Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.
Publisher c1994
Year Published 1994
Report Number EPA-R-816069; EPA/600/J-94/551;
Stock Number PB95-148128
Additional Subjects Carcinogens ; Codon ; Mutation ; DNA adducts ; Ras genes ; Pulmonary neoplasms ; Dose-response relationships ; Metabolic activation ; Pharmacokinetics ; Adenoma ; Mice ; Animal disease models ; Reprints ; Cyclopenta(cd)pyrene
Library Call Number Additional Info Location Last
NTIS  PB95-148128 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Cyclopenta(cd)pyrene (CPP) was examined for its lung tumorigenic activity in strain A/J mice, for the formation and persistence of CPP-induced DNA adducts in lung tissue, and for its induction of mutations in the Ki-ras oncogene from CPP-induced turmors. CPP displayed high tumorigenic activity, including 97.7 lung adenomas/mouse at 200 mg/kg. Ki-ras codon 12 mutations in the DNA of induced tumors were: GGT --> CGT (50%); GGT --> GTT (15%); GGT --> TGT (25%); GGT --> GAT (10%). All DNA adducts in the lungs of CPP-treated mice were CPP-3,4-oxide derived and most were CPP-3,4-oxide-2'-deoxyguanosine adducts. CPP is highly tumorigenic in the strain A/J mouse lung adenoma model, being 5 times more active than benzo(a)pyrene. The increased activity of CPP may be related to the unique induction of the GGT --> CGT, Ki-ras codon 12 mutation. (Copyright (c) 1994 Gordon and Breach Science Publishers S.A.)