Record Display for the EPA National Library Catalog

RECORD NUMBER: 38 OF 43

Main Title Two-Generation Reproductive Toxicity Evaluation of Butyl Benzyl Phthalate Administered in the Feed to CD(R) (Sprague-Dawley) Rats.
Author Tyl, R. W. ; Myers, C. B. ; Marr, M. C. ;
CORP Author Ferro Corp., Cleveland, OH. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 31 Jan 2002
Year Published 2002
Report Number OTS-89020000082 ;8EHQ-0302-14864;
Stock Number OTS-0574132-2
Additional Subjects Rats ; Reproduction ; Toxicity ; Health effects ; Weight ; Food consumption ; Cytology ; Fertility ; Lactation ; Growth ; Development ; Sprague-Dawley rats ; Benzyl phthalate
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS-0574132-2 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1092p
Abstract
The purpose of this study was to evaluate the potential of butyl benzyl phthalate (BBP), administered in the feed to CD(trademark) rats, to produce alterations in parental fertility, maternal pregnancy and lactation, and growth and development of the offspring for two generations, one litter per generation. This study was performed in compliance with U.S. EPA Toxic Substances Control Act (TSCA), Good Laboratory Practice Standards (U.S. EPA, 1989), and the U.S. EPA OPPTS Testing Guidelines (U.S. EPA, 1998). Male and female CD(trademark) (Sprague-Dawley) rats (the F0 generation) were administered BBP (1, 2-Benzenedicarboxylic acid, butyl phenylmethyl ester (9CI); CAS No. 85-68-7) in the feed at 0, 750, 3750, and 11,250 ppm, available ad libitum, 30 animals/sex/dose, for ten weeks. Body weights and feed consumption were recorded weekly, and clinical signs were recorded at least once daily. Vaginal cytology was evaluated for the last three weeks of the prebreed period. Animals were then randomly mated within treatment groups for a two-week mating period to produce the F1 generation, with exposure continuing.